Ribonuclease MRP subunit p64 (RMP64)

Ribonuclease MRP subunit p64 (RMP64) is a recently characterized, poorly understood protein component unique to the human RNase MRP ribonucleoprotein complex, an endoribonuclease essential for precursor ribosomal RNA (pre-rRNA) processing at the ITS1 site 2 in the nucleolus[1]. RMP64, together with another unique subunit (RMP24), is required for proper pre-rRNA maturation but is not necessary for RNase P activity and does not associate with the RNase P-specific H1 RNA, highlighting functional specialization[1]. It is predicted to participate in the regulation of neural progenitor differentiation and in the positive regulation of the Notch signaling pathway[2][3]. RMP64 is not an independent enzyme or receptor, nor is it a recognized therapeutic target, but rather a functional subunit of a non-coding ribonucleoprotein complex. Mutations impairing RNase MRP function (primarily through the RNA component) can lead to a spectrum of developmental and skeletal disorders, although specific roles of individual protein subunits, including RMP64, in human disease have not been defined[4].

Other names

Nucleolus and neural progenitor proteinNEPROC3orf17DKFZP434F2021NET17ANXD3protein nepro homolognucleolus and neural progenitor protein

No direct drug mechanism described or drugs known to target RMP64