Ribonuclease P protein subunit p38 (RPP38)

Ribonuclease P protein subunit p38 (RPP38) is a protein-coding gene that encodes a component of the ribonuclease P complex, a ribonucleoprotein that generates mature tRNA molecules by removing their 5'-leader sequences[1][2][3][7]. RPP38 is also a component of the MRP ribonuclease complex, which is involved in the cleavage of pre-rRNA sequences[1][7]. The protein is located in the nucleolus, specifically within the fibrillar center, and functions through RNA binding, contributing to RNA processing events essential for cellular function[1][6][7]. Disease associations include rare genetic disorders such as cartilage-hair hypoplasia and anauxetic dysplasia 1[1].

Other names

RPP38ribonuclease P/MRP subunit p38ribonuclease P protein subunit p38RNaseP protein p38ribonuclease P/MRP 38kDa subunit