Ribonuclease P RNA component H1, 2 pseudogene (RPPH1-2P)

Ribonuclease P RNA component H1, 2 pseudogene (RPPH1-2P) is a non-functional, non-coding RNA gene classified as a pseudogene[1][3]. It is related to the gene encoding the RNA subunit (RPPH1) of human ribonuclease P (RNase P), an essential ribonucleoprotein involved in tRNA processing. However, RPPH1-2P lacks protein-coding capacity and does not encode a functional product. There is currently no evidence for its role in biological processes, disease, or as a drug or biomarker target in humans[1][3]. Supporting Details and Context: - Pseudogene Status: "RPPH1-2P" is annotated as a pseudogene, meaning it is a genomic locus similar to a known functional gene (RPPH1) but generally non-functional—either not transcribed or not translated, lacking functional impact[1][3]. - Functional Parent Context: The parent gene, RPPH1, is a critical RNA subunit of RNase P, a ribonucleoprotein responsible for cleaving the 5′-end of precursor tRNAs as part of their maturation[3][5][6]. However, pseudogenes do not contribute to this activity[1][3]. - Drug Targetability and Disease Role: No documented evidence indicates RPPH1-2P is involved in disease or can be modulated by drugs[1][3]. It does not have known biological functions or interactome significance. This distinguishes it sharply from bona fide targets such as the main RPPH1 gene or RNase P holoenzyme[1][3]. - Nomenclature and Curation: The “2 pseudogene” suffix designates that this is the second (2) recognized pseudogene of the RPPH1 RNA component. There are other related pseudogenes (e.g., RPPH1-3P)[3]. Notes on curation: - There is nothing to indicate this is a misspelling; however, this is not a functional molecular target and should not be considered in a therapeutic or biomarker context[1][3]. - No data in current biomedical databases or literature suggest any disease association, molecular function, or relevance to known drugs[1][3]. - The correct, functional gene in this family is Ribonuclease P RNA component H1 (RPPH1), not RPPH1-2P.

Other names

RPPH1-2P