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Ribonucleoside-diphosphate reductase large subunit
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
The ribonucleoside-diphosphate reductase large subunit, encoded by the RRM1 gene, is a critical enzyme for DNA synthesis. It catalyzes the conversion of ribonucleotides to deoxyribonucleotides, providing essential building blocks for DNA replication and repair. As a key regulator of dNTP pools, it plays a vital role in cell proliferation, making it a validated target for anticancer therapy. It is inhibited by several chemotherapeutic agents such as gemcitabine and hydroxyurea.
- Other names
- R1RR1RIR1ribonucleotide reductase catalytic subunit M1
02
Mechanism of action
Inhibition of ribonucleotide reductase, disrupting DNA synthesis
03
Biological functions
CatalysisRegulation of dNTP poolsDNA synthesisCell proliferation
04
Disease associations
CancerWilms tumorRhabdomyosarcomaAdrenocortical carcinomaBeckwith-Wiedemann syndrome
05
Safety considerations
MyelosuppressionNeurotoxicityDrug resistanceOff-target effects
06
Interacting drugs
Gemcitabine
5 more in the full profile.
07
Biomarkers
RRM1 expression levels in tumorsPotential for patient stratification based on RRM1 expression
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