Ribonucleoside-diphosphate reductase large subunit (RRM1) (RRM1)

Ribonucleoside-diphosphate reductase large subunit (RRM1) is the catalytic component of ribonucleotide reductase, an essential enzyme for converting ribonucleotides to deoxyribonucleotides required for DNA synthesis in dividing cells. Mammalian ribonucleotide reductase consists of two non-identical subunits, with RRM1 forming the large subunit responsible for substrate binding and regulation. The enzyme activity is tightly controlled allosterically and by various effectors to ensure proper DNA replication fidelity. RRM1 is a validated anticancer target, with several drugs inhibiting its activity to limit cell proliferation and promote apoptosis in tumors. Its gene is part of an important imprinted region linked to tumor suppressor activities, and its dysregulation is implicated in cancer and certain genetic syndromes.

Other names

ribonucleotide reductase large subunit M1RRM1ribonucleoside-diphosphate reductase large subunit

Inhibition of deoxyribonucleotide synthesis—Drugs inhibit the active site or destabilize the radical necessary for catalysis, leading to DNA replication blockade and cell cycle arrest