Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribonucleotide reductase M2 subunit (RRM2)
- Target
- RRM2
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase M2 subunit (RRM2) is the small regulatory subunit of ribonucleotide reductase (RR), a key enzyme complex responsible for catalyzing the conversion of ribonucleotides to deoxyribonucleotides. This reaction provides the essential precursors for DNA synthesis, repair, and replication. Overexpression promotes tumorigenesis and correlates with poor prognosis. Inhibition or knockdown reduces tumor cell proliferation. Several inhibitors targeting RRM2 are under investigation as potential anticancer agents.
- Other names
- Ribonucleoside-diphosphate reductase subunit M2
02
Mechanism of action
Direct enzymatic inhibition; Modulation of expression/stability
03
Biological functions
Cell cycleDNA synthesisDNA repairCell proliferationNucleotide metabolismRegulation of macrophage polarization
04
Disease associations
CancerInfectionGenomic Instability
05
Safety considerations
Potential for off-target effects due to involvement in essential cellular processesDrug resistance
06
Biomarkers
RRM2 overexpression as a prognostic marker
Beyond the preview
Go deeper on Ribonucleotide reductase M2 subunit (RRM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribonucleotide reductase M2 subunit (RRM2).