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Ribonucleotide Reductase (RR)
- Target
- RR
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase (RR or RNR) is a crucial enzyme responsible for the de novo synthesis of deoxyribonucleotides from ribonucleotides. This reaction is essential for DNA synthesis and repair in all living organisms, making RR indispensable for cell proliferation and genome stability. Because RR is vital for cell proliferation, it is targeted by several anticancer drugs. Overexpression or dysregulation of certain RR subunits—especially RRM2—is associated with cancer progression and resistance mechanisms.
- Other names
- RNR
02
Mechanism of action
Inhibition of ribonucleotide reductase, disrupting dNTP supply needed for DNA synthesis.
03
Biological functions
DNA synthesisDNA repairCell proliferationGenome stabilityNucleotide metabolism
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionDrug resistanceOff-target effects
06
Interacting drugs
Hydroxyurea
4 more in the full profile.
07
Biomarkers
RRM2 overexpression
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