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Target intelligence / Profile preview
Ribonucleotide reductase catalytic subunit M1 (RRM1)
- Target
- RRM1
- Molecular classification
- Enzyme
01
Overview
RRM1 encodes the large, catalytic subunit of ribonucleotide reductase (RR), an essential enzyme for DNA synthesis. This enzyme catalyzes the conversion of ribonucleotides to deoxyribonucleotides, providing the precursors required for DNA replication and repair. The activity of RR is crucial during the S phase of dividing cells when DNA synthesis occurs. Alterations or dysregulation in this gene or its chromosomal region have been linked with various cancers and Beckwith-Wiedemann syndrome.
- Other names
- RIR1RR1ribonucleoside-diphosphate reductase large subunit
02
Mechanism of action
Ribonucleotide reductase inhibition
03
Biological functions
DNA synthesisDNA replicationDNA repairCell proliferation
04
Disease associations
CancerGenetic syndrome
05
Safety considerations
Cell cycle-dependent phosphorylation regulationSensitivity to chemotherapeutic agents
06
Interacting drugs
Gemcitabine
07
Biomarkers
RRM1 expression levels
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