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Target intelligence / Profile preview
Ribonucleotide Reductase Large Subunit (RRM1)
- Target
- RRM1
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase large subunit, also known as RRM1, is a critical enzyme in DNA synthesis and cellular metabolism. It catalyzes the biosynthesis of deoxyribonucleotides from corresponding ribonucleotides, providing the necessary precursors for DNA replication during the S phase of the cell cycle. RRM1 is a target for the chemotherapeutic agent gemcitabine and has been extensively studied as a potential biomarker in various cancer types.
- Other names
- Ribonucleotide reductase large subunit 1Ribonucleoside-diphosphate reductase large subunitRIR1RR1
02
Mechanism of action
RRM1 serves as a cellular target for the chemotherapeutic agent gemcitabine
03
Biological functions
DNA synthesisDeoxyribonucleotide biosynthesisCell proliferationRegulation of cell migration
04
Disease associations
Cancer
05
Interacting drugs
Gemcitabine
06
Biomarkers
RRM1 mRNA expression levelsRRM1 genetic variants
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