Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribonucleotide Reductase Large Subunit M1 (RRM1)
- Target
- RRM1
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase large subunit M1 (RRM1) is the catalytic subunit of ribonucleoside-diphosphate reductase, an enzyme essential for DNA synthesis. It catalyzes the reduction of ribonucleotides to deoxyribonucleotides. RRM1 is a therapeutic target in various cancers due to its role in cell proliferation and dNTP production.
- Other names
- Ribonuclotide reductase M1RR M1Ribonuclotide-diphosphate reductase large subunit
02
Mechanism of action
Induce DNA replication stress by blocking dNTP supply during S phase
03
Biological functions
DNA synthesisCell proliferationdNTP productionElectron transfer
04
Disease associations
CancerBeckwith-Wiedemann syndromeWilms tumorRhabdomyosarcomaAdrenocortical carcinomaLung cancerOvarian cancerBreast cancer
05
Safety considerations
Potential toxicity associated with disrupting essential DNA synthesis pathways
06
Interacting drugs
Small molecule inhibitors targeting RRM1
07
Biomarkers
Overexpression of RRM1 as a prognostic marker for poor survival outcomes in gastric and colorectal cancer
Beyond the preview
Go deeper on Ribonucleotide Reductase Large Subunit M1 (RRM1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribonucleotide Reductase Large Subunit M1 (RRM1).