Ribonucleotide reductase M2 (RRM2)

Ribonucleotide reductase M2 (RRM2) is the small regulatory subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis and repair. It catalyzes the conversion of ribonucleotides to deoxyribonucleotides, providing the precursors necessary for DNA replication and cell proliferation. The activity of RRM2 is tightly regulated in a cell cycle-dependent manner, with expression peaking during S-phase. Overexpression correlates with increased tumor growth, poor prognosis, and drug resistance, making it a potential therapeutic target in various cancers.

Other names

RR2RR2MRibonucleotide reductase regulatory subunit M2Ribonucleoside-diphosphate reductase subunit M2

Inhibition of ribonucleotide reductase activity to reduce the supply of deoxynucleotide triphosphates (dNTPs), thereby blocking DNA replication and cell proliferation.