Ribonucleotide Reductase R2 Subunit (RRM2)

The ribonucleotide reductase R2 subunit (RRM2, M2, or R2) is a critical component of the ribonucleotide reductase (RNR) enzyme complex, which catalyzes the reduction of ribonucleotides to deoxyribonucleotides—the essential precursors for DNA synthesis and repair. It is a homodimer, where each monomer harbors a dinuclear iron center that is crucial for generating and stabilizing a tyrosyl radical, which initiates the radical-based chemistry required for nucleotide reduction. Overexpression or dysregulation of RRM2 has been linked with increased tumorigenesis, cancer progression, and drug resistance. It is a therapeutic target in oncology.

Other names

M2R2Ribonucleside-diphosphate reductase small chainRR small chainRR regulatory subunitRNR-RBRegulatory Subunit MII/MIIb/RB

Inhibition of ribonucleotide reductase activity by scavenging tyrosyl radicals, thereby blocking DNA synthesis.