Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribonucleotide reductase regulatory subunit M2 (RRM2)
- Target
- RRM2
- Molecular classification
- Enzyme, Oxidoreductase, Ribonucleoside diphosphate reductase small chain family
01
Overview
Ribonucleotide reductase regulatory subunit M2 (RRM2) is the small regulatory subunit of ribonucleotide reductase (RR), an essential enzyme for DNA synthesis and repair. It catalyzes the conversion of ribonucleotides to deoxyribonucleotides, providing precursors necessary for DNA replication and repair. RRM2 is essential for cell proliferation and its overexpression or dysregulation is linked to various cancers, making it a potential therapeutic target.
- Other names
- RR2RR2MRibonucleoside-diphosphate reductase subunit M2Ribonucleotide reductase small chain/subunit
02
Mechanism of action
Inhibition of ribonucleotide reductase activity, leading to depletion of deoxyribonucleotides.
03
Biological functions
DNA synthesisDNA repairCell proliferationCell cycle progressionRegulation of Wnt signaling
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the essential role of RRM2 in normal cell function.Development of drug resistance in cancer cells.
06
Biomarkers
RRM2 overexpression as a prognostic marker in cancer
Beyond the preview
Go deeper on Ribonucleotide reductase regulatory subunit M2 (RRM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribonucleotide reductase regulatory subunit M2 (RRM2).