Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribonucleotide reductase small subunit M2 (RRM2)
- Target
- RRM2
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase small subunit M2 (RRM2) is an essential enzyme for DNA synthesis and repair. It catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Its expression is cell cycle-dependent, and dysregulation is linked to cancer proliferation. RRM2 is considered a therapeutic target and a potential biomarker for cancer prognosis.
- Other names
- RR2RR2MRibonucleoside-diphosphate reductase subunit M2
02
Mechanism of action
Catalyzes the conversion of ribonucleotides to deoxyribonucleotides, providing precursors required for DNA synthesis.
03
Biological functions
DNA synthesisCell cycle regulationDe novo dNTP biosynthesis
04
Disease associations
Cancer
05
Safety considerations
Overexpression or dysregulation can lead to enhanced cancer cell proliferation.Inhibition of Wnt signaling
06
Biomarkers
Prognostic marker in various cancers
Beyond the preview
Go deeper on Ribonucleotide reductase small subunit M2 (RRM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribonucleotide reductase small subunit M2 (RRM2).