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Target intelligence / Profile preview
Ribonucleotide reductase small subunit R2 (RRM2)
- Target
- RRM2
- Molecular classification
- Enzyme
01
Overview
Ribonucleotide reductase small subunit R2 (RRM2) is a crucial component of the ribonucleotide reductase (RNR) enzyme, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides, essential precursors for DNA synthesis and repair. It contains a stable tyrosyl radical required for catalysis. RRM2 expression is tightly regulated during the cell cycle, and it is a key target for anticancer drugs like hydroxyurea.
- Other names
- R2RR2RR2MRibonucleoside-diphosphate reductase subunit M2RR M2RR SSBM MII
02
Mechanism of action
Inhibition of ribonucleotide reductase activity by scavenging tyrosyl radicals, leading to decreased dNTP production and inhibition of DNA synthesis.
03
Biological functions
CatalysisDNA synthesisDNA repairCell proliferationNucleotide metabolismEpithelial-mesenchymal transition
04
Disease associations
Cancer
05
Safety considerations
Potential for drug resistance through mutationsSide effects associated with chemotherapeutic agents
06
Interacting drugs
Hydroxyurea
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