Ribonucleotide reductase subunit 1 (RRM1)

Ribonucleotide reductase subunit 1 (RRM1) is the large subunit of ribonucleotide reductase, a key enzyme that catalyzes the reduction of ribonucleoside diphosphates to deoxyribonucleoside diphosphates, providing the essential precursors for DNA synthesis and repair[1][4]. RRM1, together with the small subunit (RRM2 or RRM2B in humans), forms the active enzyme complex and is regulated allosterically to balance the relative concentrations of deoxyribonucleotides required for DNA replication and cell division[1]. Ribonucleotide reductase activity is vital for cell proliferation, and its inhibition forms the basis of several anti-cancer and antiviral therapies. Abnormal expression or dysregulation of RRM1 is associated with altered sensitivity to chemotherapeutics and with various malignancies, making it both a therapeutic target and a predictive biomarker[1][4].

Other names

RRM1Ribonucleotide reductase large subunitRibonucleoside-diphosphate reductase large chainRNR large subunit

Inhibition of deoxyribonucleotide synthesis (prevents DNA synthesis and repair by limiting the supply of deoxynucleotides)