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Ribonucleotide Reductase Subunit M1 (RRM1)

Target: RRM1
Molecular classification: Enzyme

Overview

Ribonucleotide reductase subunit M1 (RRM1) is the large catalytic subunit of the enzyme ribonucleotide reductase (RNR). This enzyme plays a crucial role in DNA synthesis and cell proliferation by catalyzing the conversion of ribonucleotides to deoxyribonucleotides, which are essential precursors for DNA synthesis. RRM1 is a target for anticancer drugs, such as hydroxyurea, which inhibits ribonucleotide reductase activity. Drug-resistant cell lines may overexpress RRM1 as a mechanism of resistance.

Mechanism of action

Inhibition of ribonucleotide reductase activity

Biological functions

DNA synthesisRegulation of DNA synthesisCell proliferation

Disease associations

CancerBeckwith-Wiedemann syndrome

Safety considerations

Drug resistance

Interacting drugs

Hydroxyurea

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