Ribonucleotide reductase subunit R1 (None)

Ribonucleotide reductase subunit R1 is a critical component of ribonucleotide reductase (RNR), an essential enzyme responsible for the de novo synthesis of deoxyribonucleotides from ribonucleotides. This reaction provides the building blocks required for DNA synthesis and repair, making RNR indispensable for cell proliferation and survival. It catalyzes the reduction of ribonucleoside diphosphates (NDPs) to their corresponding deoxyribonucleoside diphosphates (dNDPs), which are then further phosphorylated to form dNTPs, the direct precursors for DNA synthesis. Plays a key regulatory role in maintaining balanced dNTP pools within cells, ensuring high fidelity during DNA replication and repair processes. The activity of RNR is tightly regulated throughout the cell cycle to match cellular demands for DNA synthesis. Overexpression or dysregulation is associated with cancer progression. It serves as an established target for anticancer drugs such as hydroxyurea and gemcitabine that inhibit its function directly or indirectly.

Other names

R1 subunit of ribonucleotide reductaseLarge subunit of ribonucleotide reductaseRRM1

Inhibition of ribonucleotide reductase activity, leading to depletion of dNTPs and inhibition of DNA synthesis