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Target intelligence / Profile preview
Ribonucleotide Reductase Subunit R2 (RRM2)
- Target
- RRM2
- Molecular classification
- Enzyme, Ribonucleotide Reductase Subunit
01
Overview
Ribonucleotide reductase subunit R2 (RRM2) is the small subunit of ribonucleotide reductase (RR), a crucial enzyme complex responsible for catalyzing the reduction of ribonucleotides to deoxyribonucleotides. This reaction provides the essential precursors for DNA synthesis and repair. RRM2 contains a dinuclear iron center and a tyrosyl radical essential for its function. Overexpression or dysregulation of RRM2 has been linked to cancer development, making it a target for anticancer drug development.
- Other names
- R2Ribonucleoside-diphosphate reductase large subunitRNR-R2
02
Mechanism of action
Inhibition of ribonucleotide reductase activity by targeting the tyrosyl radical site on RNR-R2
03
Biological functions
DNA synthesisDNA repairCell proliferationdNTP biosynthesisCell cycle
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential for off-target effects due to the essential role of RRM2 in normal cell functionDevelopment of resistance mechanisms in cancer cells
06
Interacting drugs
Hydroxyurea
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