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Ribosomal 40S Subunit (None)

Target: None
Molecular classification: Ribosomal Subunit, RNA-protein complex

Overview

The ribosomal 40S subunit is the small subunit of the eukaryotic cytoplasmic ribosome, a large RNA–protein complex responsible for translating messenger RNA (mRNA) into proteins. It plays a crucial role in decoding mRNA and ensuring correct tRNA-mRNA pairing during protein synthesis. The 40S subunit is a validated, druggable target.

Mechanism of action

Inhibition of protein synthesis by disrupting mRNA binding, tRNA selection, or subunit assembly.

Biological functions

mRNA decodingTranslation initiationProtein synthesis

Disease associations

CancerRibosomopathiesViral infections (target for antiviral drugs)

Safety considerations

Off-target effects on mitochondrial ribosomesPotential for broad-spectrum toxicity due to essential role in protein synthesis

Interacting drugs

Various translation inhibitors (e.g., some antibiotics)

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