Ribosomal L24 domain-containing protein 1 (RSL24D1)

Ribosomal L24 domain-containing protein 1 (RSL24D1) is a highly conserved nucleolar protein essential for the biogenesis of the eukaryotic 60S ribosomal subunit[1][3]. RSL24D1 is analogous to the yeast RLP24 and functions in several steps of large subunit assembly, notably pre-rRNA transcription and processing, and influences global protein synthesis[1][3]. It interacts with the RNA polymerase I subunit RPA194 and the PeBoW complex, coordinating ribosomal RNA production with ribosome assembly[1][4]. While not a classical therapeutic target such as a receptor or enzyme, its critical role in ribosome biogenesis links RSL24D1 to regulation of cell growth, pluripotency maintenance, stress response via p53, and disease states like cancer and familial hypercholesterolemia[1][3]. Depletion disrupts ribosomal assembly, triggers ribosomal stress pathways, and impairs protein synthesis, highlighting its essential cellular function. No known drugs directly target RSL24D1, nor is it considered a standard therapeutic target at this time.

Other names

Probable ribosome biogenesis protein RLP24RSL24D1C15orf15RPL24LMY024HRP-L30-isoL30RPL24TVAS360S ribosomal protein L30 isologHomolog of yeast ribosomal like protein 24My024 protein

Not targeted pharmacologically. The molecule acts by interacting with the RNA polymerase I complex and other ribosome assembly factors (e.g., PeBoW complex), regulating pre-rRNA transcription and 60S subunit maturation[1][4].