Ribosomal peptidyl transferase center–nascent MYC polypeptide complex (PTC-nascent MYC complex)

The Ribosomal peptidyl transferase center–nascent MYC polypeptide complex is a specialized state of the human ribosome during the translation of the MYC oncogene. This complex forms when the nascent MYC protein sequence interacts with the ribosomal exit tunnel, creating a unique structural pocket at the peptidyl transferase center (PTC). While MYC has long been considered undruggable due to its lack of traditional small-molecule binding sites, recent research has identified this specific ribosome-nascent chain complex as a viable therapeutic target. Small molecules can selectively bind to this complex, inducing translational stalling and preventing the production of the MYC protein. This approach offers a novel strategy for treating MYC-driven cancers by targeting the machinery of protein synthesis in a sequence-specific manner. By inhibiting the completion of MYC translation, these drugs effectively reduce the levels of one of the most potent drivers of tumor growth and survival.

Other names

Ribosome-nascent MYC chain complexMYC-RNCRibosomal peptidyl transferase center-nascent c-Myc complex

Small molecule binding to the ribosomal peptidyl transferase center (PTC) specifically when the nascent MYC polypeptide is present in the exit tunnel, inducing translational stalling and subsequent degradation of the MYC-nascent chain complex.