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Target intelligence / Profile preview
Ribosomal Protein L12-L10 Complex (L12-L10 Complex)
- Target
- L12-L10 Complex
- Molecular classification
- Ribosomal protein complex, Protein-protein interaction
01
Overview
The Ribosomal Protein L12-L10 Complex is a crucial pentameric structure (L10(L12)_4) in the prokaryotic ribosome's large (50S) subunit. It functions as the ribosomal stalk, essential for recruiting translation elongation factors (EF-G, EF-Tu) and stimulating GTPase activity during protein synthesis. L10 anchors the stalk to the ribosome by binding to 23S rRNA. Disruption of this interaction impairs translation, making it a promising target for novel antibiotics, particularly against pathogens like Mycobacterium tuberculosis. The complex also autoregulates its own expression through feedback repression at the mRNA leader sequence.
- Other names
- Ribosomal stalkL10(L12)_4 complexRibosomal protein stalk complex
02
Mechanism of action
Inhibition of L12-L10 interaction, leading to impaired translation elongation and bacterial growth.
03
Biological functions
Translation elongation factor recruitmentGTPase activationProtein synthesisAutoregulation of ribosomal protein expression
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on eukaryotic ribosomes.Development of resistance mechanisms.
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