Ribosomal protein L12 pseudogene 35 (RPL12P35)

Ribosomal protein L12 pseudogene 35 (RPL12P35) is a processed pseudogene corresponding to the ribosomal protein L12 gene. Pseudogenes are non-functional segments of DNA that resemble functional genes but generally do not produce active proteins. RPL12P35 itself is not known to encode a functional protein or play a direct role in biological processes or disease. Its presence is mostly relevant in the context of genome annotation and evolutionary studies. Confusion can arise because the functional ribosomal protein L12 (encoded by RPL12) is a component of the ribosome involved in protein synthesis[3][5], whereas RPL12P35 is simply one of many pseudogene copies of that gene found scattered in the human genome[4][2][8]. The functional ribosomal protein L12 (RPL12) is an essential ribosomal protein found in the 60S subunit, involved in protein translation and associated with certain diseases[3][5]. The pseudogene RPL12P35 does not encode an active protein and is not a valid drug target, receptor, enzyme, transporter, etc. Pseudogenes like RPL12P35 are mainly catalogued for genomics purposes; their function, if any, is rarely well established[8]. No evidence supports RPL12P35 as a biomarker, drug target, therapeutic risk, or biological actor. If you sought the functional ribosomal protein, RPL12 (ribosomal protein L12), those entries would differ substantially.

Other names

RPL12 pseudogene 35RPL12_13_1452

Not applicable; pseudogenes do not generally have mechanisms of action relevant to drug targeting