Ribosomal protein L13a pseudogene 21 (RPL13AP21)

RPL13AP21 is a processed pseudogene located on human chromosome 16:20073021-20073499[10]. It is a retrocopy of the parental RPL13A gene, which encodes ribosomal protein L13a, a member of the ribosomal 60S subunit. As a pseudogene, RPL13AP21 does not code for a functional protein[1][4][10][12]. Like other processed pseudogenes, it arises via reverse transcription of RPL13A mRNA and reintegration into the genome. There is no evidence that RPL13AP21 is expressed or has any protein-coding function, biological activity, or disease relevance. It should not be considered a therapeutic target. The functional RPL13A gene plays roles in ribosome structure and in inflammatory regulation via the GAIT complex, but RPL13AP21 is a nonfunctional copy that does not participate in these processes[5][10]. The presence of many ribosomal protein pseudogenes, including RPL13AP21, is typical in the human genome[3][5]. RPL13AP21 is a non-functional processed pseudogene and is not a receptor, enzyme, transporter, nor a molecule with therapeutic interest. It is not druggable and has no described role as a biomarker or in disease[1][4][10][12].

Other names

RPL13A_10_1231RPL13AP21[1][6]