Ribosomal protein L21 pseudogene 125 (RPL21P125)

Ribosomal protein L21 pseudogene 125 (RPL21P125) is a processed pseudogene; it does not encode a functional protein and is not an active component of the ribosome or involved in protein synthesis. Pseudogenes are typically non-functional remnants of genes that have lost their ability to code for a protein, and they are common for ribosomal protein genes due to their evolutionary history. As such, RPL21P125 is not a therapeutic target, does not have a known biological function, disease association, or pharmacological relevance [1][4]. The functional gene in this family is ribosomal protein L21 (RPL21), which encodes a protein component of the 60S large ribosomal subunit [3][4]. Multiple pseudogenes for ribosomal proteins exist, including many with similar names, but these are generally non-functional [3][4]. There is something "wrong" with this target for drug discovery purposes: as a pseudogene, RPL21P125 is not a therapeutically relevant molecule and does not serve as a receptor, enzyme, transporter, or any other typical molecular drug target [1][4]. Direct genetic information for pseudogenes such as RPL21P125 is limited to gene product catalogs and databases, with no evidence for biological function or disease association [1]. The functional RPL21 gene codes for a structurally relevant ribosomal protein [3][4], but pseudogenes like RPL21P125 are non-coding, non-therapeutic, and not of practical clinical or research utility.

Other names

RPL21P125RPL21_55_1506