Ribosomal protein L21 pseudogene 41 (RPL21P41)

Ribosomal protein L21 pseudogene 41 (RPL21P41) is one of many processed pseudogenes derived from the functional ribosomal protein L21 (RPL21) gene. Pseudogenes such as RPL21P41 are DNA sequences that resemble functional genes but harbor disabling mutations which prevent them from encoding functional proteins. The human genome contains over 140 RPL21 pseudogenes, reflecting the gene's status as a highly expressed housekeeping gene prone to retrotransposition and duplication. RPL21P41 does not produce a functional ribosomal protein and has no established biological or therapeutic role. The parent gene, RPL21, encodes a component of the large (60S) ribosomal subunit, essential for protein synthesis in human cells. RPL21 and its functional protein are associated with peptide chain elongation and involved in the clinical phenotype of hypotrichosis simplex when mutated. Pseudogenes are a common feature in highly expressed genes like ribosomal proteins and GAPDH. The large number of RPL21 pseudogenes are a result of retrotransposition events, but these loci do not encode active protein and are annotated as non-coding. RPL21P41 itself has no known function, is not associated with disease, and is not the subject of drug development or biomarker research. If you are seeking structured information for the functional ribosomal protein rather than the pseudogene, the correct entry would be Ribosomal protein L21 (RPL21), not RPL21P41.

Other names

RPL21P41ribosomal protein L21 pseudogene