Ribosomal protein L21 pseudogene 85 (RPL21P85)

Ribosomal protein L21 pseudogene 85 (RPL21P85) is a processed pseudogene in the human genome, originating from the gene encoding ribosomal protein L21[1][11]. Processed pseudogenes arise when reverse-transcribed mRNA is inserted into the genome, typically resulting in nonfunctional sequences due to lack of regulatory elements or disabling mutations[2]. RPL21P85 does not produce a protein and is not known to play a regulatory or functional role. Its presence is typical of ribosomal protein genes, which often have many pseudogenes dispersed through the genome due to their high expression and retrotranspositional activity[2][1][7]. There is no evidence that RPL21P85 acts as a receptor, enzyme, transporter, or other druggable target[1][3][11]. The associated functional gene, ribosomal protein L21 (RPL21), is implicated in ribosome assembly and several diseases, but the pseudogene itself has no known direct association with pathology or therapeutics[9][11][7].\n\nKey clarifications:\n- RPL21P85 is not a receptor, enzyme, transporter, or functional protein[1][11].\n- It is not considered a drug target and has no known biological, disease, or biomarker relevance[1][11].\n- The functional gene RPL21 (not the pseudogene) is related to ribosomal protein function and associated with certain genetic diseases, but this does not apply to RPL21P85[5][9].

Other names

RPL21_33_996RPL21P85[4][11]