Ribosomal protein L23a pseudogene 14 (RPL23AP14)

Ribosomal protein L23a pseudogene 14 (RPL23AP14) is a **processed pseudogene** of the ribosomal protein L23a (RPL23A) gene, meaning it is a non-coding, nonfunctional gene copy located in the human genome that does not produce a functional protein[1][4][6]. Pseudogenes like RPL23AP14 arise from gene duplication or retrotransposition events and may serve as evolutionary genomic elements but do not have a recognized canonical molecular function or therapeutic relevance. Pseudogenes in general can sometimes be transcriptionally active and may play regulatory roles, but there is currently no evidence that RPL23AP14 encodes a protein or acts as a therapeutic/receptor/enzymatic target. The notation “pseudogene 14” distinguishes it from other RPL23A pseudogenes present in the genome; the parent RPL23A gene encodes a component of the 60S ribosomal subunit involved in protein synthesis[3][5]. No drugs target RPL23AP14, and it has no known role in disease pathogenesis or as a therapeutic biomarker. There are no safety concerns associated with targeting this pseudogene, as it is nonfunctional and not a drug target.

Other names

RPL23A_29_1192hCG1642354RPL23AP14