Ribosomal protein L23a pseudogene 28 (RPL23AP28)

**Ribosomal protein L23a pseudogene 28 (RPL23AP28)** is a processed pseudogene related to the ribosomal protein L23A gene (RPL23A)[3]. The functional RPL23A gene encodes a structural protein that is part of the 60S subunit of cytoplasmic ribosomes, playing a role in protein synthesis[1][3]. However, RPL23AP28 itself is classified as a pseudogene and does not encode a functional protein. Humans and other mammals have multiple such processed pseudogenes for ribosomal proteins due to their evolutionary history[3]. There is no evidence that RPL23AP28 (nor the many other RPL23A pseudogenes) acts as a messenger RNA, functional noncoding RNA, or therapeutic target. Pseudogenes like RPL23AP28 are generally not transcribed or translated, and there is no information associating this specific pseudogene with disease phenotypes, therapeutic approaches, diagnostic biomarkers, or drug targets[3]. **Key clarifications:** - RPL23A is a protein-coding gene crucial for ribosome function, with links to disorders such as Diamond-Blackfan anemia and other syndromes when mutated or dysregulated[1][3]. - **RPL23AP28 is a pseudogene**—a non-functional segment of DNA that arose by retrotransposition or duplication of RPL23A and subsequent loss of function[3]. - Recent research on other RPL23A pseudogenes (e.g., RPL23AP53) shows that some pseudogenes may have regulatory roles, but no such evidence is available for RPL23AP28[4][5]. The reference to RPL23AP53 should not be generalized to RPL23AP28 without evidence. - There are no known drugs, mechanisms of action, or safety concerns associated with RPL23AP28. **Summary for database structuring:** RPL23AP28 is a pseudogene (not a target, enzyme, receptor, or protein), and most fields relevant to functional proteins or drug targets are null or not applicable in this context.

Other names

RPL23A_10_329RPL23AP28