Target intelligence / Profile preview

Ribosomal protein L23a pseudogene 33 (RPL23AP33)

Target
RPL23AP33
Molecular classification
Other, Pseudogene, Long non-coding RNA (lncRNA)
01

Overview

Ribosomal protein L23a pseudogene 33 (RPL23AP33) is a **processed pseudogene** of the ribosomal protein L23a gene, meaning it is a non-coding RNA sequence in the human genome that resembles the functional RPL23A gene but does not encode a functional protein product[1][2][6]. Pseudogenes such as RPL23AP33 can function as long non-coding RNAs (lncRNAs) and have been implicated in gene regulation, but they do not serve as classical therapeutic targets like receptors, enzymes, or transporters[1][5]. Studies on closely related pseudogenes (e.g., RPL23AP53) suggest that their expression levels may be associated with cellular proliferation and prognosis in cancer (such as melanoma), and thus could potentially serve as novel biomarkers, but there is no evidence indicating that RPL23AP33 itself is druggable or interacts with any therapeutic compounds[5].

Other names
RPL23A_7_304RPL23AP33
02

Biological functions

Other (putative regulatory non-coding RNA function; does not code for a functional protein)Potential association with cellular proliferation
03

Disease associations

Other (no direct role, but dysregulation associated with altered prognosis and immune profiles in melanoma)
04

Biomarkers

Potential prognostic biomarker in melanoma[5]

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