Target intelligence / Profile preview

Ribosomal protein L23a pseudogene 81 (RPL23AP81)

Target
RPL23AP81
Molecular classification
Other (Pseudogene), Not a protein-coding gene, nor a receptor, enzyme, transporter, or transcription factor[1][6][7][8]
01

Overview

RPL23AP81 (Ribosomal protein L23a pseudogene 81) is a processed pseudogene in the human genome, meaning it is a region of DNA similar to the ribosomal protein L23a gene but generally non-functional (does not encode a functional protein)[1][6][7][8]. As with other pseudogenes, it likely arose via duplication and retrotransposition of the functional RPL23A gene, but it lacks the necessary regulatory elements or coding sequence integrity to produce a working protein. There are no direct reports of regulatory, structural, or pathological functions associated with RPL23AP81 specifically. The canonical ribosomal protein L23a (RPL23A) itself is a component of the large ribosomal 60S subunit and is involved in protein translation, but relevance of RPL23AP81 is limited to gene annotation and genomic studies rather than functional biology or drug targeting[1][5][7][8]. Notes on validity: - This target is misspecified for therapeutic or biomarker studies: RPL23AP81 is not a receptor, enzyme, transporter, or any canonical drug target class[1][6][7][8]. It is a pseudogene with no recognized biological role or disease association. - Information about other related pseudogenes (e.g., RPL23AP53) must not be conflated with RPL23AP81 for therapeutic or diagnostic purposes[3]. Summary conventions: - Correct capitalization and nomenclature used. - RPL23AP81 should not be considered a therapeutic target. - Return "true" for "is_incorrect" because the target is not valid for therapeutic, mechanistic, or biomarker investigation.

Other names
RPL23AP81RPL23A_40_1702RPL23A pseudogene 81
02

Mechanism of action

None. No drugs or therapeutic agents act on RPL23AP81.

03

Biological functions

No direct biological function; pseudogenes are generally non-functional remnants of gene duplication events.There is increasing evidence that some pseudogenes may act as competitive endogenous RNAs (ceRNAs), molecular sponges for microRNAs, or have regulatory effects, but there is no evidence for such a function for RPL23AP81 specifically[3].
04

Disease associations

No known disease association for RPL23AP81 specifically.Other ribosomal protein L23a pseudogenes (such as RPL23AP53) have shown possible associations with cancer progression and immune profiles, but this has not been demonstrated for RPL23AP81[3].Diseases such as Diamond-Blackfan Anemia and Dyskeratosis Congenita are associated with functional RPL23A, not the pseudogene[5].
05

Safety considerations

None. It is not studied or targeted therapeutically.
06

Interacting drugs

None. There are no known drugs targeting pseudogene RPL23AP81[2][6][8].
07

Biomarkers

None. RPL23AP81 is not used as a biomarker in diagnostics or monitoring.

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