Ribosomal protein L24 pseudogene 4 (RPL24P4)

Ribosomal protein L24 pseudogene 4 (RPL24P4) is a **processed pseudogene** of the RPL24 gene that does not encode a functional ribosomal protein. Like other processed pseudogenes, RPL24P4 has traditionally been considered non-functional but emerging evidence demonstrates that it is highly expressed in human gliomas and associated with poor prognosis and enhanced tumor invasiveness. Knockdown of RPL24P4 in glioma cell lines reduces proliferation, migration, and invasion, suggesting a role as a long non-coding RNA or regulatory RNA in cancer biology. RPL24P4 also correlates with the level of tumor-associated M2 macrophages, implicating it in immune microenvironment modulation. Thus, while **not a therapeutic target in the traditional sense (e.g., receptor, enzyme, transporter)**, RPL24P4 is a potential **biomarker** and candidate for RNA-based interventions in cancer, especially glioma[2][8][7]. **Key clarifications:** - RPL24P4 is not a protein-coding gene and is distinguished from the canonical ribosomal protein target RPL24[1][5][3]. - It is not considered a direct therapeutic target under standard definitions; there are currently no known drugs or mechanistic drug actions directly targeting this pseudogene[2][8]. - Its main significance is as a prognostic biomarker and potential regulatory molecule in tumor progression, not as a receptor or enzyme[2].

Other names

dJ125M3.1RPL24_1_69260S ribosomal proteinribosomal protein L24 pseudogene 4RPL24P4