Ribosomal protein L27a pseudogene (RPL27AP)

RPL27AP (ribosomal protein L27a pseudogene) is a pseudogene corresponding to ribosomal protein L27a. Unlike protein-coding genes, pseudogenes typically do not encode functional proteins and do not have an established biological, enzymatic, or signaling role. RPL27AP is a non-functional, likely non-transcribed genomic DNA segment derived from the ancestral RPL27A gene. It is not considered a therapeutic target, receptor, enzyme, transporter, or disease biomarker and does not participate in signaling pathways or drug interactions. The annotation “dJ1028D15.2” is an alternative clone or transcript ID. RPL27AP is a processed pseudogene—a genomic segment that arose from the retrotransposition of the ribosomal protein L27a gene (RPL27A) and subsequently lost its protein-coding function, often due to mutations (such as frameshifts or premature stop codons). “Ribosomal protein L27a” (RPL27A) is an authentic ribosomal protein component of the large (60S) ribosomal subunit, but RPL27AP refers specifically to its pseudogene, which is not translated into a functional protein. Pseudogenes like RPL27AP are not active in protein synthesis, are not involved in recognized diseases directly, and have no documented interactions with therapeutic drugs or roles as therapeutic targets. This entry is not a therapeutic target and not relevant for drug mechanism or safety monitoring. For structural data, clinical relevance, or molecular targeting, the canonical form would be “Ribosomal protein L27a” (RPL27A), but “RPL27AP” is its noncoding pseudogene.

Other names

dJ1028D15.2