Ribosomal protein L32 pseudogene 3 (RPL32P3)

Ribosomal protein L32 pseudogene 3 (RPL32P3) is a non-protein-coding pseudogene related to the parental ribosomal protein L32 gene (RPL32). It is mapped to human chromosome 3q21.3. Unlike its parental gene, RPL32P3 does not code for a ribosomal protein but has been implicated in regulating gene expression in certain contexts, such as glioma-exposed endothelial cells, where it affects blood–tumor barrier permeability and may play a role in tumor biology. Pseudogenes like RPL32P3 are generally considered non-functional remnants of genes, but some, including RPL32P3, can have regulatory effects on cellular processes, particularly in cancer biology[1]. RPL32P3 is a pseudogene, not an active protein, enzyme, receptor, or druggable target. In drug discovery and therapeutic biology, pseudogenes are usually not considered therapeutic targets unless specifically proven to be druggable, which is not the case here[1]. The term "ribosomal protein L32 pseudogene" could refer to any of many related pseudogenes (e.g., RPL32P1, RPL32P3, RPL32P32, etc.), so without further disambiguation, the target is ambiguous[4][6]. No drugs, biomarkers, or safety concerns are associated; its function is non-canonical and mainly regulatory, as observed in some cancer studies[1]. Overall, Ribosomal protein L32 pseudogene 3 (RPL32P3) is not a canonical molecular target; it is a non-coding pseudogene that may have regulatory roles in gene expression, particularly in cancer (glioma), but it is not a therapeutic receptor, enzyme, transporter, or drug target[1].

Other names

RPL32P3ribosomal protein L32 pseudogene 3RPL32-pseudogene

None known; no established mechanism as a therapeutic target