Ribosomal protein L35 pseudogene 5 (RPL35P5)

Ribosomal protein L35 pseudogene 5 (RPL35P5) is one of several non-functional DNA sequences in the human genome that closely resembles the gene encoding ribosomal protein L35 but contains mutations or truncations that prevent it from encoding a functioning protein. These pseudogenes arise from gene duplication or retrotransposition events and are typically transcriptionally inactive, although in some contexts, ribosomal protein pseudogenes are reported to regulate the expression of their functional parent genes via RNA-mediated mechanisms such as acting as competing endogenous RNAs (ceRNAs) or sources of short interfering RNAs. There is no evidence that RPL35P5 encodes a ribosomal protein or acts as a therapeutic target[5][9][11]. Key points: - RPL35P5 does not encode an active protein, and while ribosomal protein pseudogenes may play regulatory roles in some cases, there is no evidence of a direct biological or disease-specific function or of surface/druggable properties as a target[5][9][11]. - This entry is not a functional receptor, enzyme, transporter, or similar therapeutic target; it should not be used for canonical target definitions in pharmacological or clinical screening pipelines. - If you need information about a functional ribosomal protein L35, use RPL35, not RPL35P5[1][10]. If a canonical, functional ribosomal target is required, Ribosomal protein L35 (RPL35) is the appropriate entry, not this pseudogene.

Other names

RPL35_4_812RPL35P5[2][9]