Ribosomal protein L35a pseudogene 20 (RPL35AP20)

Ribosomal protein L35a pseudogene 20 (RPL35AP20) is a processed pseudogene found in the human genome. It is derived from the functional RPL35A gene, which encodes the 60S ribosomal protein L35a, a structural component of the ribosome's large subunit involved in protein synthesis. Pseudogenes like RPL35AP20 do not produce functional proteins and are generally non-coding; however, emerging research suggests that pseudogene transcripts can participate in regulatory functions, such as acting as decoys for miRNAs or influencing gene expression at the RNA level. There is no evidence that RPL35AP20 is linked to a particular disease, used as a biomarker, interacts with drugs, or is a validated therapeutic target. Its sole recognized role is as a genomic relic closely related to its parental gene. RPL35A is a protein-coding gene and mutations in it are associated with diseases like Diamond-Blackfan anemia, but the pseudogene RPL35AP20 is distinct, non-coding, and not associated with those disease mechanisms. There is nothing incorrect with the target entry itself, though because it is a pseudogene, it is not druggable nor a direct research focus for therapeutic intervention. Pseudogene nomenclature (the "P" in "RPL35AP20") typically indicates a non-functional derivative unless otherwise demonstrated. This mapping follows conventions for molecular targets, noting that pseudogenes are, by definition, not active therapeutic targets but can sometimes have subtle regulatory roles.

Other names

RPL35A_9_959Previous GeneCards Identifiers (e.g., GC09P006667, GC09P006677, etc.)