Ribosomal protein L36a-like (RPL36AL)

Ribosomal protein L36a-like (RPL36AL) is a structural protein component of the large 60S subunit of cytoplasmic ribosomes, the organelles responsible for protein synthesis[4][5][7]. The protein is highly similar in sequence to yeast ribosomal protein L44 and belongs to the L44E (L36AE) family of ribosomal proteins[4][5]. RPL36AL is encoded by a protein-coding gene that lacks introns in its coding regions, which likely resulted from retrotransposition of its X-linked homolog[2][10]. RPL36AL and its close paralog, RPL36A, encode nearly identical proteins but are distinct genes[5][7]. RPL36AL is ubiquitously expressed and is important for the functioning of the ribosome[2]. While mutations or dysfunction in ribosomal proteins may be implicated in some diseases through disruption of protein synthesis (notably Diamond-Blackfan anemia and rare cancer associations), RPL36AL itself is not currently considered a direct drug target or therapeutic receptor/enzyme/transporter[7]. There is no evidence of direct safety concerns, mechanism-based drug interactions, or biomarker utility related to this protein. RPL36AL is mainly relevant as a basic ribosomal protein contributing to core cell biology rather than as a regulatory target or therapeutic intervention point.

Other names

Ribosomal protein L36a-likeRPL36ALRibosomal protein eL42-like60S ribosomal protein L36a-likeLarge ribosomal subunit protein eL42-likeRPL36ARPL36AP42RPL36A_18_1363HL44Ribosomal protein L36a pseudogene 42

Not applicable; there are currently no drugs known to target this protein specifically[7].