Ribosomal protein L36a pseudogene 8 (RPL36AP8)

Ribosomal protein L36a pseudogene 8 (RPL36AP8) is a pseudogene in the human genome, meaning it is a genomic sequence similar to a known gene but generally considered non-functional in terms of protein-coding ability[1][2][6][8]. It is classified as a processed pseudogene related to the ribosomal protein L36a (RPL36A), a component of the large 60S ribosomal subunit responsible for protein synthesis[7][9]. Unlike RPL36A, the RPL36AP8 pseudogene is not believed to encode a functional protein product[1][6]. Like other pseudogenes, RPL36AP8 might have potential regulatory roles through its RNA, such as functioning as a competitive endogenous RNA ("miRNA decoy"), but there is no current evidence or consensus for disease associations, direct biomarker relevance, or involvement in therapeutic drug targeting for RPL36AP8 specifically[4]. The presence of multiple processed pseudogenes for ribosomal protein genes like RPL36A is typical in the human genome[9]. The approved gene name and symbol ("ribosomal protein L36a pseudogene 8," RPL36AP8) is established by the HUGO Gene Nomenclature Committee[6][8]. This gene is categorized solely as a pseudogene, not as a receptor, enzyme, transporter, or transcription factor[1][6]. Its only relevant “family” is the pseudogene group related to ribosomal proteins. There are no documented interacting drugs, therapeutic mechanisms, or established biomarker roles for RPL36AP8. There is no evidence that RPL36AP8 has direct disease involvement or safety concerns. While pseudogene transcripts in general can influence gene expression by regulating their functional homologs (as shown for other pseudogenes such as PTENP1 and KRASP1)[4], there are no published reports of such functions for RPL36AP8. Ribosomal protein L36a pseudogene 8 (RPL36AP8) is a human processed pseudogene related to the ribosomal protein L36a gene, with no evidence for direct protein-coding function, disease association, therapeutic targeting, or biomarker utility at this time[1][2][4][6].

Other names

RPL36A_20_1424