Ribosomal protein L37 pseudogene 18 (RPL37P18)

RPL37P18 encodes a processed pseudogene corresponding to ribosomal protein L37, which is a component of the 60S ribosomal subunit in humans[3][5][7]. Pseudogenes such as RPL37P18 do not typically produce functional proteins and are generally not considered therapeutic targets or biomarkers. The parental gene (RPL37) is located on chromosome 5 and encodes a ribosomal protein essential for protein synthesis; many processed pseudogenes for ribosomal proteins exist throughout the genome as remnants of gene duplication and retrotransposition processes[5][7]. While some ribosomal protein pseudogenes may be transcriptionally active and dysregulated in certain cancers, their biological roles and functional significance remain unclear, and they are not recognized in clinical therapeutics or diagnostics[2]. The human genome contains numerous ribosomal protein pseudogenes, including RPL37P18, most of which reside in GC-poor regions and result from random insertions. They can occasionally be transcribed, sometimes at levels approaching those of their parent genes depending on tissue type, but the functional documentation is sparse. Unlike the parent ribosomal proteins, pseudogenes such as RPL37P18 have not been linked definitively to cell cycle regulation, apoptosis, or other cellular processes, nor to specific disease roles such as cancer, inflammation, or drug resistance[2][3][7]. There is no established clinical, signaling, or drug-interaction relevance for RPL37P18. If you meant the functional ribosomal protein L37, refer to “RPL37” (not RPL37P18), which has a defined protein product, specific molecular and biological classifications, and limited disease associations (e.g., anemia, cataract)[5][7].

Other names

RPL37P18RPL37_8_1033