Ribosomal protein L7a pseudogene 81 (RPL7AP81)

Ribosomal protein L7a pseudogene 81 (RPL7AP81) is a non-coding pseudogene in humans on chromosome 1, annotated as Gene ID 122965333[11][16][14]. It shares high sequence similarity with the protein-coding gene for ribosomal protein L7a (RPL7A), but RPL7AP81 does not encode a functional protein[1][11][16]. Like other ribosomal protein pseudogenes, its sequence is a genomic relic of the parent gene and is classified as a processed pseudogene, likely the result of retrotransposition events during evolution[13][12]. There is no evidence this pseudogene encodes a therapeutic drug target, a receptor, enzyme, transporter, or a functional protein. Some pseudogenes can play RNA-level regulatory roles (such as acting as miRNA decoys or as sources of regulatory siRNAs in specific contexts), but there is no information linking RPL7AP81 to such functions[2][5][12]. The parent gene, RPL7A, encodes a ribosomal 60S subunit protein central to protein synthesis in human cells[4][7][10]. Multiple pseudogenes are reported for RPL7A, of which RPL7AP81 is one. RPL7AP81 is not actionable for therapeutics, does not interact with drugs, and has no biomarker or safety concern associations.

Other names

RPL7AP81