Ribosomal protein S10 pseudogene 31 (RPS10P31)

Ribosomal protein S10 pseudogene 31 (RPS10P31, ENSG00000213752) is a processed pseudogene associated with the parental protein-coding gene for ribosomal protein S10, a component of the eukaryotic 40S ribosomal subunit[1][3][7]. Pseudogenes like RPS10P31 are DNA sequences that are highly similar to a functional gene but are typically non-functional due to disabling mutations, such as frameshifts or premature stop codons, and usually do not produce functional RNA or protein[1][2][3][9]. Most ribosomal protein pseudogenes, including this one, do not encode active proteins and do not participate in canonical biological processes or disease pathways attributed to their parental gene[1][3][7]. Because pseudogenes lack normal gene structure or essential regulatory elements, they are not considered valid therapeutic targets, biomarkers, or drivers of disease, nor are they associated with drugs, mechanisms of action, or safety concerns[1][3][9]. Hence, while Ribosomal protein S10 (RPS10) is important in ribosome assembly and function, its pseudogenes—including RPS10P31—are not biologically functional nor clinically relevant as molecular targets[1][3][7][9]. Key points: - Not a therapeutic target: Pseudogenes, by definition, do not produce active proteins and therefore cannot be targeted by drugs[2][3][9]. - Not implicated in disease or biological function: Pseudogenes such as RPS10P31 are not known to play active roles in any disease or cellular function[1][3][10]. - Potential for confusion: The presence of many similarly named ribosomal protein pseudogenes in the genome increases risk for annotation errors; this entry is correctly a pseudogene, not a protein-coding gene[1][3]. References: [1][3][7][9][10]

Other names

Ribosomal protein S10 pseudogeneRPS10_16_1758RPS10P31ENSG00000213752