Ribosomal protein S15a pseudogene 12 (RPS15AP12)

Ribosomal protein S15a pseudogene 12 (RPS15AP12) is a processed pseudogene transcribed as a long noncoding RNA that does not encode a functional protein but exerts regulatory effects in cancer. It acts as a molecular “sponge” for miR-96-3p, preventing this microRNA from repressing RPS15A, thus promoting RPS15A expression. RPS15AP12 enhances the growth, migration, and metastatic capacity of ovarian cancer cells and suppresses innate immune signaling through inhibition of RIG-I/MDA5 and downstream interferon pathways. RPS15AP12 is not a traditional therapeutic target as it is a noncoding pseudogene, but it may play a functional role in cancer progression and could potentially be considered for future biomarker or RNA-based therapeutic strategies.

Other names

RPS15AP12RPS15A_5_166

Acts as a competitive endogenous RNA (ceRNA) sequestering miR-96-3p, thereby promoting the expression of its parent gene, RPS15A.