Ribosomal protein S15a pseudogene 14 (RPS15AP14)

Ribosomal protein S15a pseudogene 14 (RPS15AP14) is a **processed pseudogene** in the human genome that shares high sequence identity with the functional ribosomal protein S15a gene (RPS15A), which encodes a component of the 40S ribosomal subunit involved in protein synthesis. Unlike the parent gene, this pseudogene does not produce a functional protein and is not known to play a role in cellular biology, disease, or pharmacology. Pseudogenes like RPS15AP14 typically arise from duplication or retrotransposition events and lack the regulatory elements or coding capacity for active involvement in biological pathways[1][3][5][8]. ### Additional Context and Supporting Details - **Not a protein-coding gene:** RPS15AP14 is annotated as a non-functional pseudogene rather than a gene encoding a functional protein[1]. - **Molecular classification:** It falls into the “Other” category, as it does not fit classic druggable target classes (e.g., receptor, enzyme, transporter)[1]. - **No therapeutic or disease relevance:** There is no evidence supporting RPS15AP14 as a therapeutic target, biomarker, or disease-associated gene, and it has no known drug interactions[1][5]. - **Alias clarity:** The name RPS15AP14 distinguishes it from its functional counterpart, RPS15A[1][5]. - **Functional parent gene:** The parent gene, RPS15A, is involved in ribosome assembly and protein synthesis, and mutations in the functional gene (not pseudogene) are linked to conditions like Diamond-Blackfan anemia[5][8]. No evidence suggests that "RPS15AP14" is incorrectly named or refers to another entity, nor is it considered a therapeutic target, receptor, or druggable protein based on current genomic databases and gene annotation resources[1][5][8].

Other names

RPS15A_4_297RPS15AP14