Ribosomal protein S15a pseudogene 22 (RPS15AP22)

The ribosomal protein S15a pseudogene 22 (RPS15AP22; ENSG00000236395) is a nonfunctional genomic DNA segment that closely resembles the functional RPS15A gene which encodes a component of the 40S ribosomal subunit. As a pseudogene, RPS15AP22 has lost its protein-coding ability and does not contribute to ribosome structure or function. There is no evidence for clinical relevance, biomarker utility, or therapeutic targeting of this locus. Pseudogenes like RPS15AP22 are widespread in the genome and generally do not encode functional protein products. While a few pseudogenes have regulatory functions or roles in RNA-based regulation in some settings, most, including RPS15AP22, have no described biological or disease-associated function and are not therapeutic targets. These sequences typically serve as markers of genomic evolution rather than as actionable drug targets. No standard drugs, disease associations, or safety concerns are known for this gene. Their annotation sometimes causes confusion in bioinformatics or genetic studies due to sequence similarity with functional genes.

Other names

RPS15A_11_848RPS15AP22ENSG00000236395NCBI GeneID: 100271557GC07U902593GC07M131386

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