Ribosomal protein S18 pseudogene 12 (RPS18P12)

RPS18P12 is a processed pseudogene derived from the ribosomal protein S18 gene[1][2]. It represents one of multiple pseudogenes that arose from the functional RPS18 gene, which encodes the 40S ribosomal protein S18 - a component of the small ribosomal subunit involved in protein synthesis[5]. Pseudogenes are non-functional gene copies that have accumulated mutations over evolutionary time, rendering them unable to produce functional proteins[5]. RPS18P12 is classified as a processed pseudogene, meaning it was likely derived from an mRNA intermediate that was reverse transcribed and integrated into the genome[6]. The human genome contains numerous ribosomal protein pseudogenes, with RPS18 having at least 12 identified pseudogene copies including RPS18P12[6][9]. The functional RPS18 gene encodes a ribosomal protein that belongs to the S13P family and is located in the cytoplasm as part of the 40S ribosomal subunit[5]. However, RPS18P12 itself does not encode a functional protein and is not considered a therapeutic target. The pseudogene has the NCBI Gene ID 388339 and Ensembl ID ENSG00000230897[2][4]. While ribosomal proteins have been studied in the context of various diseases and cellular processes, RPS18P12 as a pseudogene does not have established roles in disease pathogenesis or as a therapeutic target[6][7].

Other names

RPS18_4_1516

Not applicable (pseudogene)