Ribosomal protein S18 pseudogene 13 (RPS18P13)

Ribosomal protein S18 pseudogene 13 is a processed pseudogene derived from the ribosomal protein S18 gene, located in the human genome. Pseudogenes like RPS18P13 originate from retrotransposition or duplication events, resulting in non-functional gene copies that typically lack regulatory elements or are disrupted by mutations[1][8][13]. While the parent gene, ribosomal protein S18, is an essential component of the small 40S ribosomal subunit involved in protein synthesis[4][7], RPS18P13 does not contribute to ribosome structure or function and is generally considered biologically inert[8][13]. The parent gene, RPS18, is vital for protein synthesis and associated with diseases like Diamond-Blackfan Anemia when mutated[7]. As a pseudogene, RPS18P13 has no known protein product, biological activity, disease role, biomarker utility, or drug interactions[1][5][13]. Pseudogenes sometimes serve as markers of genomic evolution or may be used in genomic studies, but do not serve as therapeutic targets[8]. Pseudogene annotation (e.g., "ribosomal protein S18 pseudogene 13") strictly indicates non-coding DNA lacking a productive role in cell biology[1][2][5][13].

Other names

RPS18_8_1634RPS18P13