Ribosomal protein S18 pseudogene 14 (RPS18P14)

Ribosomal protein S18 pseudogene 14 (RPS18P14) is one of numerous processed pseudogenes derived from the ribosomal protein S18 gene (RPS18), which encodes a protein component of the 40S ribosomal subunit in eukaryotic cells[10][11][5][8]. Pseudogenes like RPS18P14 are generally non-functional stretches of DNA resembling functional genes but lacking the ability to encode active protein due to mutations or truncations acquired during evolution[5][8]. While some pseudogenes exert regulatory roles, there is no evidence that RPS18P14 has any such function. The canonical, protein-coding version of the gene (RPS18) is essential for ribosome assembly and protein synthesis, and disruptions to its function can result in diseases such as Diamond-Blackfan anemia[10]. However, RPS18P14 itself is not implicated in disease, is not a therapeutic target, and is not associated with drug interactions or biomarker utility. Ribosomal protein S18 pseudogene 14 is strictly a pseudogene and should not be considered a protein target, receptor, enzyme, transporter, or other actionable sequence in drug discovery or molecular medicine[11][5][8]. If searching for a molecular target in the ribosomal protein family, refer to the canonical protein-coding gene RPS18 (ribosomal protein S18), not RPS18P14.

Other names

RPS18_10_1747RPS18P14

None applicable