Ribosomal protein S2 pseudogene 1 (RPS2P1)

Ribosomal protein S2 pseudogene 1 (RPS2P1) is a processed pseudogene of the functional ribosomal protein S2 (RPS2) gene. It shares high sequence similarity with RPS2 but does not produce a functional protein due to sequence disruptions typical of processed pseudogenes. RPS2P1 is not involved in protein synthesis, cellular pathways, or any recognized disease processes. Such pseudogenes reflect the evolutionary history of gene families and are distributed throughout the genome as nonfunctional relics of gene duplication and retrotransposition events[3]. The functional RPS2 gene encodes a protein of the 40S ribosomal subunit[1][2][5]. RPS2P1 is one of many processed pseudogenes found for ribosomal proteins in the human genome; the term processed means it originated via reverse transcription and integration of mRNA without regulatory sequences or introns, resulting in loss of protein-coding ability[3]. There is no evidence that RPS2P1 is involved in any human diseases or is targetable by drugs. Therefore, RPS2P1 is a noncoding pseudogene, not a therapeutic target.

Other names

dJ64K7.1RPS2_26_1696RPS2P1