Ribosomal protein S2 pseudogene 23 (RPS2P23)

Ribosomal protein S2 pseudogene 23 (RPS2P23) is a non-functional genomic DNA sequence that shares homology with the ribosomal protein S2 gene, which encodes a component of the 40S ribosomal subunit involved in protein synthesis[1][6]. However, as a pseudogene, RPS2P23 does not code for a functional protein and lacks biological activity. Pseudogenes such as RPS2P23 commonly arise from reverse transcription and genomic integration of processed mRNA and may have some regulatory roles through RNA interference mechanisms, although for this specific pseudogene, no direct functional or disease associations have been reported[6][8]. It is not considered a therapeutic target due to the absence of protein-coding ability or clinical relevance[1][6]. RPS2 (the parent gene) is a well-studied ribosomal protein involved in translation and associated with some disease roles, but RPS2P23 functions only as a pseudogene without proven biological or clinical significance[3][4]. Over 50 processed pseudogenes for RPS2 have been identified in the human genome, with the majority exhibiting typical disabling mutations (frameshifts, stop codons), and they are distributed randomly throughout the genome[6]. In summary, RPS2P23 (ribosomal protein S2 pseudogene 23) is not a receptor, enzyme, transporter, or any classical drug target; it is a non-functional pseudogene and therefore not relevant for therapeutic targeting, interaction with drugs, or disease association.

Other names

RPS2_10_570RPS2P23